JHI essays on Durkheim, Wittgenstein, Spengler et al and their theories on society versus the individual.

The combination of rhetoric and philosophy appeared in the ancient world through Cicero, and revived as an ideal in the Renaissance. By a careful and precise analysis of the views of four major humanists-Petrarch, Salutati, Bruni, and Valla—Professor Seigel seeks to establish that they were first of all professional rhetoricians, completely committed to the relation between philosophy and rhetoric. He then explores the broader problem of the "external history" of humanism, and reopens basic questions about Renaissance culture. He departs from (...) the views held by such scholars as Hans Baron and Lauro Martines and expands the conclusions suggested by Paul Oskar Kristeller. The result is a stimulating, controversial study that rejects some of the claims made for the humanists and indicates achievements and limitations. Originally published in 1968. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

The combination of rhetoric and philosophy appeared in the ancient world through Cicero, and revived as an ideal in the Renaissance. By a careful and precise analysis of the views of four major humanists-Petrarch, Salutati, Bruni, and Valla—Professor Seigel seeks to establish that they were first of all professional rhetoricians, completely committed to the relation between philosophy and rhetoric. He then explores the broader problem of the "external history" of humanism, and reopens basic questions about Renaissance culture. He departs from (...) the views held by such scholars as Hans Baron and Lauro Martines and expands the conclusions suggested by Paul Oskar Kristeller. The result is a stimulating, controversial study that rejects some of the claims made for the humanists and indicates achievements and limitations. Originally published in 1968. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

ABSTRACTMary Darby Robinson is well known for writing her final volume of poems, the Lyrical Tales, as a direct answer, sometimes poem by poem, to Wordsworth and Coleridge’s 1798 Lyrical Ballads. What has been less studied is how deliberately hybrid in style and allusions her response-poems are in the Tales, especially how prominently they foreground Gothic imagery, theatricality, and hyperbole in poems that also ape the emerging “romantic” mode of the Ballads themselves. Part of that “cheekiness,” I argue, stems from (...) the condemnation of the Gothic that both Wordsworth and especially Coleridge had articulated in print, while also echoing it, albeit in highly modified ways, in their poetry. Most of what Robinson attempts with her hybrid Tales, though, develops the penchant in Gothic for symbolizing deep and unresolved ideological conflicts in Western culture. Her answers to Wordsworth and Coleridge, which I exemplify with selected Robinson Tales, therefore, bring out those very conflicts underlying,... (shrink)

The coronavirus disease-2019 (COVID-19) has caused shortages of life-sustaining medical resources, and future waves of the virus may cause further scarcity. The Yale New Haven Health System developed a triage protocol to allocate scarce medical resources during the COVID-19 pandemic, with the primary goal of saving the most lives possible, and a secondary goal of making triage assessments and decisions consistent, transparent, and fair. We outline the process of developing the protocol, summarize the protocol, and discuss the major ethical challenges (...) encountered, along with our answers to the challenges. These challenges include (1) the role of age and chronic comorbidities; (2) evaluating children and pregnant patients; (3) racial, ethnic, and socioeconomic disparities in health; (4) prioritization of healthcare workers; and (5) balancing clinical judgment versus protocolized assessments.We conclude with a review of the limitations of our protocol and the lessons learned. We hope that a robust public discussion of such protocols and the ethical challenges they raise will result in the fairest possible processes, less need for triage, and more lives saved during future waves of the pandemic and similar public health emergencies. (shrink)

Subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead “anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the (...) STN produces similar clinical efficacy.” These discrepancies likely result from methodological differences including targeting preferences, imaging acquisition and the use of brain atlases that do not account for patient-specific anatomic variability. We present a first-in-kind within-patient demonstration of severe mood side effects and minimal motor improvement in a Parkinson’s disease patient following placement of a DBS lead in the limbic/associative territory of the STN who experienced marked improvement in motor benefit and resolution of mood side effects following repositioning the lead within the STN sensorimotor territory. 7 Tesla magnetic resonance imaging data were used to generate a patient-specific anatomical model of the STN with parcellation into distinct functional territories and computational modeling to assess the relative degree of activation of motor, associative and limbic territories. (shrink)